Because of its physical properties, honokiol can readily cross the blood brain barrier and the blood-cerebrospinal fluid barrier.
2.
Increased sPLA2 activity is observed in the cerebrospinal fluid of humans with Alzheimer's disease and multiple sclerosis, and may serve as a marker of increases in permeability of the blood-cerebrospinal fluid barrier.
3.
The "'blood cerebrospinal fluid barrier "'( "'BCSFB "') is a pair of barriers that separates peripheral and cerebral blood flow from the cerebrospinal fluid ( CSF );
4.
The BBB is distinct from the quite similar blood cerebrospinal fluid barrier, which is a function of the choroidal cells of the choroid plexus, and from the blood retinal barrier, which can be considered a part of the whole realm of such barriers.
5.
The neuroimmune system of the brain is structurally distinct from the peripheral immune system which protects the rest of the body; in particular, the immune system is composed primarily of hematopoietic cells and anatomical barriers, while the neuroimmune system is composed of glia, mast cells, and various brain barriers ( e . g ., blood brain barrier and blood-cerebrospinal fluid barrier ).
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